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While rhabdomyolysis has previously been reported after several months of tirzepatide therapy, the present case is notable for the onset of this adverse effect following a single supratherapeutic dose ( In conclusion, the underlying pathophysiological mechanism remains uncertain

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5.1 Risk of Thyroid C-cell Tumors Liraglutide causes dose-dependent and treatment-duration-dependent thyroid C-cell tumors (adenomas and/or carcinomas) at clinically relevant exposures in both genders of rats and mice [see Nonclinical Toxicology (13.1)]